A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease

Alireza Faridar; Abdulmunaim M. Eid; Aaron D. Thome; Weihua Zhao; David R. Beers; Maria B. Pascual; Mohammad O. Nakawah; Gustavo C. Roman; Charles S. Davis; Michael Grundman; Joseph C. Masdeu; Stanley H. Appel

doi:10.1186/s40035-023-00387-5

Translational Neurodegeneration (Nov 2023)

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease

Alireza Faridar,
Abdulmunaim M. Eid,
Aaron D. Thome,
Weihua Zhao,
David R. Beers,
Maria B. Pascual,
Mohammad O. Nakawah,
Gustavo C. Roman,
Charles S. Davis,
Michael Grundman,
Joseph C. Masdeu,
Stanley H. Appel

Affiliations

Alireza Faridar: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Abdulmunaim M. Eid: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Aaron D. Thome: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Weihua Zhao: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
David R. Beers: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Maria B. Pascual: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Mohammad O. Nakawah: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Gustavo C. Roman: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Charles S. Davis: CSD Biostatistics, Inc.
Michael Grundman: Global R&D Partners, LLC
Joseph C. Masdeu: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute
Stanley H. Appel: Stanley H. Appel Department of Neurology, Houston Methodist Research Institute

DOI: https://doi.org/10.1186/s40035-023-00387-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 4

Abstract

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Trial registration ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153

Published in Translational Neurodegeneration

ISSN: 2047-9158 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://translationalneurodegeneration.biomedcentral.com

About the journal