Toxicologic Concerns with Current Medical Nanoparticles

Tsai-Mu Cheng; Hsiu-Yi Chu; Haw-Ming Huang; Zi-Lin Li; Chiang-Ying Chen; Ya-Jung Shih; Jacqueline Whang-Peng; R. Holland Cheng; Ju-Ku Mo; Hung-Yun Lin; Kuan Wang

doi:10.3390/ijms23147597

International Journal of Molecular Sciences (Jul 2022)

Toxicologic Concerns with Current Medical Nanoparticles

Tsai-Mu Cheng,
Hsiu-Yi Chu,
Haw-Ming Huang,
Zi-Lin Li,
Chiang-Ying Chen,
Ya-Jung Shih,
Jacqueline Whang-Peng,
R. Holland Cheng,
Ju-Ku Mo,
Hung-Yun Lin,
Kuan Wang

Affiliations

Tsai-Mu Cheng: Graduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
Hsiu-Yi Chu: Graduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
Haw-Ming Huang: School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
Zi-Lin Li: Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan
Chiang-Ying Chen: Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan
Ya-Jung Shih: Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan
Jacqueline Whang-Peng: Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan
R. Holland Cheng: Department of Molecular & Cellular Biology, University of California, Davis, CA 95616, USA
Ju-Ku Mo: Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
Hung-Yun Lin: Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan
Kuan Wang: Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan

DOI: https://doi.org/10.3390/ijms23147597
Journal volume & issue: Vol. 23, no. 14
p. 7597

Abstract

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Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles changes, the physiological response of the cells can be very different. Several characteristics of NPs such as the composition, surface chemistry, surface charge, and shape are also important parameters affecting the toxicity of nanomaterials. This review covered specific topics that address the effects of NPs on nanomedicine. Furthermore, mechanisms of different types of nanomaterial-induced cytotoxicities were described. The distributions of different NPs in organs and their adverse effects were also emphasized. This review provides insight into the scientific community interested in nano(bio)technology, nanomedicine, and nanotoxicology. The content may also be of interest to a broad range of scientists.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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