Nature Communications (Nov 2021)

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

  • Joshua S. Woodworth,
  • Helena Strand Clemmensen,
  • Hannah Battey,
  • Karin Dijkman,
  • Thomas Lindenstrøm,
  • Raquel Salvador Laureano,
  • Randy Taplitz,
  • Jeffrey Morgan,
  • Claus Aagaard,
  • Ida Rosenkrands,
  • Cecilia S. Lindestam Arlehamn,
  • Peter Andersen,
  • Rasmus Mortensen

DOI
https://doi.org/10.1038/s41467-021-26934-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell response to TB and increases protection.