Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Roman S. Pavelyev; Rusalia M. Vafina; Konstantin V. Balakin; Oleg I. Gnezdilov; Aleksey B. Dobrynin; Olga A. Lodochnikova; Rashid Z. Musin; Galina A. Chmutova; Svetlana A. Lisovskaya; Liliya E. Nikitina

doi:10.1155/2018/3589342

Journal of Chemistry (Jan 2018)

Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Roman S. Pavelyev,
Rusalia M. Vafina,
Konstantin V. Balakin,
Oleg I. Gnezdilov,
Aleksey B. Dobrynin,
Olga A. Lodochnikova,
Rashid Z. Musin,
Galina A. Chmutova,
Svetlana A. Lisovskaya,
Liliya E. Nikitina

Affiliations

Roman S. Pavelyev: Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia
Rusalia M. Vafina: Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia
Konstantin V. Balakin: Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia
Oleg I. Gnezdilov: Kazan E. K. Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, Sibirsky Tract, 10/7, Kazan 420029, Russia
Aleksey B. Dobrynin: A.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, Russia
Olga A. Lodochnikova: A.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, Russia
Rashid Z. Musin: A.E. Arbuzov Institute of Organic and Physical Chemistry; KazSC, Russian Academy of Sciences, Arbuzova 8, Kazan 420088, Russia
Galina A. Chmutova: Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, Russia
Svetlana A. Lisovskaya: Kazan Scientific and Research Institute of Epidemiology and Microbiology, Bolshaya Krasnaya 67, Kazan 420015, Russia
Liliya E. Nikitina: Kazan State Medical University, Butlerova 49, Kazan 420012, Russia

DOI: https://doi.org/10.1155/2018/3589342
Journal volume & issue: Vol. 2018

Abstract

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Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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