Proceedings (Aug 2019)
Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs
- Konstantin Volcho,
- Alexandra Zakharenko,
- Olga Luzina,
- Tatyana Khomenko,
- Evgeniy Suslov,
- Oksana Salomatina,
- Olga Zakharova,
- Nikolai Li-Zhulanov,
- Jóhannes Reynisson,
- Olga Lavrik,
- Nariman Salakhutdinov
Affiliations
- Konstantin Volcho
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Alexandra Zakharenko
- Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
- Olga Luzina
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Tatyana Khomenko
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Evgeniy Suslov
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Oksana Salomatina
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Olga Zakharova
- Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
- Nikolai Li-Zhulanov
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- Jóhannes Reynisson
- School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand
- Olga Lavrik
- Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
- Nariman Salakhutdinov
- Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
- DOI
- https://doi.org/10.3390/proceedings2019022035
- Journal volume & issue
-
Vol. 22,
no. 1
p. 35
Abstract
The cytotoxic effects of chemotherapy and radiation that are clinically used to treat malignancies are directly related to their propensity to generate DNA damage. [...]
Keywords
- anticancer agent
- Tdp1 inhibitor
- DNA repair enzyme
- synthesis
- usnic acid
- pentathiepine
- adamantane
- molecular modeling
- terpene
- coumarin
