A Novel
<i>Toxoplasma</i>
Inner Membrane Complex Suture-Associated Protein Regulates Suture Protein Targeting and Colocalizes with Membrane Trafficking Machinery

Jessica H. Chern; Rebecca R. Pasquarelli; Andy S. Moon; Allan L. Chen; Jihui Sha; James A. Wohlschlegel; Peter J. Bradley

doi:10.1128/mBio.02455-21

mBio (Oct 2021)

A Novel <i>Toxoplasma</i> Inner Membrane Complex Suture-Associated Protein Regulates Suture Protein Targeting and Colocalizes with Membrane Trafficking Machinery

Jessica H. Chern,
Rebecca R. Pasquarelli,
Andy S. Moon,
Allan L. Chen,
Jihui Sha,
James A. Wohlschlegel,
Peter J. Bradley

Affiliations

Jessica H. Chern: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
Rebecca R. Pasquarelli: Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA
Andy S. Moon: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
Allan L. Chen: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
Jihui Sha: Department of Biological Chemistry and Institute of Genomics and Proteomics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
James A. Wohlschlegel: Department of Biological Chemistry and Institute of Genomics and Proteomics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Peter J. Bradley: ORCiD; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA

DOI: https://doi.org/10.1128/mBio.02455-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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The inner membrane complex (IMC) is a peripheral membrane and cytoskeletal system that is organized into intriguing rectangular plates at the periphery of the parasite. The IMC plates are delimited by an array of IMC suture proteins that are tethered to both the membrane and the cytoskeleton and are thought to provide structure to the organelle.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal