Nature Communications (Jun 2022)

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

  • Valentina Scabia,
  • Ayyakkannu Ayyanan,
  • Fabio De Martino,
  • Andrea Agnoletto,
  • Laura Battista,
  • Csaba Laszlo,
  • Assia Treboux,
  • Khalil Zaman,
  • Athina Stravodimou,
  • Didier Jallut,
  • Maryse Fiche,
  • Philip Bucher,
  • Giovanna Ambrosini,
  • George Sflomos,
  • Cathrin Brisken

DOI
https://doi.org/10.1038/s41467-022-30898-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The role of progesterone receptor (PR) and its interplay with estrogen receptor (ER) in breast cancer is controversial. Here, the authors demonstrate that PR can have an ER-independent role in breast cancer growth and metastasis and that its effects are dependent on MYC and androgen receptor signatures.