ImmunoTargets and Therapy (Dec 2013)
Implications of chemokine receptors and inflammatory lipids in cancer
Abstract
Johannes Rolin, Azzam A Maghazachi Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway Abstract: Inflammatory lipids receive much attention due to their important biological activities. Knowledge of the chemokine system has also reached a level that makes it interesting in clinics, which prompted clinical trials into compounds manipulating chemokines or their receptors. However, little attention has been devoted to understand the relations between these two systems. Here, we will review the role of inflammatory lipids and chemokines in innate and adaptive immunity with an attempt to link the two systems and with emphasis on their importance in cancer development. Keywords: chemokines, FTY720, HODE, linoleic acid, sphingosine 1-phosphate
