Structural basis for plazomicin antibiotic action and resistance

Tolou Golkar; Angelia V. Bassenden; Krishnagopal Maiti; Dev P. Arya; T. Martin Schmeing; Albert M. Berghuis

doi:10.1038/s42003-021-02261-4

Communications Biology (Jun 2021)

Structural basis for plazomicin antibiotic action and resistance

Tolou Golkar,
Angelia V. Bassenden,
Krishnagopal Maiti,
Dev P. Arya,
T. Martin Schmeing,
Albert M. Berghuis

Affiliations

Tolou Golkar: Department of Biochemistry, McGill University, McIntyre Medical Building
Angelia V. Bassenden: Department of Biochemistry, McGill University, McIntyre Medical Building
Krishnagopal Maiti: Department of Chemistry, Clemson University
Dev P. Arya: Department of Chemistry, Clemson University
T. Martin Schmeing: Department of Biochemistry, McGill University, McIntyre Medical Building
Albert M. Berghuis: Department of Biochemistry, McGill University, McIntyre Medical Building

DOI: https://doi.org/10.1038/s42003-021-02261-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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Golkar, Bassenden et al. report two structures of the latest generation aminoglycoside antibiotic plazomicin in complex with the bacterial 70S ribosome as well as in complex with AAC(2’)-la acetyltransferase, an antibiotic modification enzyme (AME). Their study can be useful in the development of newer aminoglycosides that are not modified by AMEs while being capable of targeting the bacterial ribosome.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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