Spatial accuracy evaluation of magnetic source imaging methods on OPM-based MEG

Nan An; Fuzhi Cao; Wen Li; Wenli Wang; Weinan Xu; Chunhui Wang; Min Xiang; Yang Gao; Binbin Sui; Dawei Wang; Dexin Yu; Xiaolin Ning

iScience (Oct 2022)

Spatial accuracy evaluation of magnetic source imaging methods on OPM-based MEG

Nan An,
Fuzhi Cao,
Wen Li,
Wenli Wang,
Weinan Xu,
Chunhui Wang,
Min Xiang,
Yang Gao,
Binbin Sui,
Dawei Wang,
Dexin Yu,
Xiaolin Ning

Affiliations

Nan An: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Fuzhi Cao: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Wen Li: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Wenli Wang: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Weinan Xu: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Chunhui Wang: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China
Min Xiang: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Research Institute of Frontier Science, Beihang University, Beijing 100191, China
Yang Gao: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; School of Physics, Beihang University, Beijing 100191, China
Binbin Sui: Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
Dawei Wang: Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China; Shandong Key Laboratory: Magnetic Field-free Medicine and Functional Imaging, Jinan 250012, China; Research Institute of Shandong University: Magnetic Field-free Medicine and Functional Imaging, Jinan 250012, China
Dexin Yu: Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China; Shandong Key Laboratory: Magnetic Field-free Medicine and Functional Imaging, Jinan 250012, China; Research Institute of Shandong University: Magnetic Field-free Medicine and Functional Imaging, Jinan 250012, China
Xiaolin Ning: Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou 310051, China; Research Institute of Frontier Science, Beihang University, Beijing 100191, China; Corresponding author

Journal volume & issue: Vol. 25, no. 10
p. 105177

Abstract

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Summary: The emergence of the optically pumped magnetometer (OPM)-based magnetoencephalography (MEG) has led to new developments in MEG technology. The source imaging results of different magnetic source imaging (MSI) methods show considerable differences, which makes it difficult for researchers to choose an appropriate method. This study assessed time-domain MSI methods implemented in the Brainstorm, FieldTrip, and SPM12 toolboxes using simulations. We proposed using a metric, variational free energy under the Bayesian framework, as an indicator to evaluate source imaging results because it does not require the ground truth of sources but uses the fitness of the measurement data. Our simulations demonstrated the effectiveness of the variational free energy in indicating the quality of the source reconstruction results. We then applied each MSI method to the real OPM-MEG experimental data. We aimed to highlight the characteristics of each method and provide references for researchers choosing an appropriate MSI method.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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