Nature Communications (Feb 2017)
Infection-derived lipids elicit an immune deficiency circuit in arthropods
- Dana K. Shaw,
- Xiaowei Wang,
- Lindsey J. Brown,
- Adela S. Oliva Chávez,
- Kathryn E. Reif,
- Alexis A. Smith,
- Alison J. Scott,
- Erin E. McClure,
- Vishant M. Boradia,
- Holly L. Hammond,
- Eric J. Sundberg,
- Greg A. Snyder,
- Lei Liu,
- Kathleen DePonte,
- Margarita Villar,
- Massaro W. Ueti,
- José de la Fuente,
- Robert K. Ernst,
- Utpal Pal,
- Erol Fikrig,
- Joao H. F. Pedra
Affiliations
- Dana K. Shaw
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Xiaowei Wang
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Lindsey J. Brown
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Adela S. Oliva Chávez
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Kathryn E. Reif
- United States Department of Agriculture, Animal Disease Research Unit, Agriculture Research Service
- Alexis A. Smith
- Department of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland
- Alison J. Scott
- Department of Microbial Pathogenesis, University of Maryland School of Dentistry
- Erin E. McClure
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Vishant M. Boradia
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Holly L. Hammond
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Eric J. Sundberg
- Departments of Medicine and Microbiology and Immunology, Institute of Human Virology, University of Maryland School of Medicine
- Greg A. Snyder
- Departments of Medicine and Microbiology and Immunology, Institute of Human Virology, University of Maryland School of Medicine
- Lei Liu
- Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Kathleen DePonte
- Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Margarita Villar
- SaBio. Instituto de Investigación en Recursos Cinegéticos IREC, CSIC-UCLM-JCCM
- Massaro W. Ueti
- United States Department of Agriculture, Animal Disease Research Unit, Agriculture Research Service
- José de la Fuente
- SaBio. Instituto de Investigación en Recursos Cinegéticos IREC, CSIC-UCLM-JCCM
- Robert K. Ernst
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Utpal Pal
- Department of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland
- Erol Fikrig
- Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Joao H. F. Pedra
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- DOI
- https://doi.org/10.1038/ncomms14401
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.
