Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family

Ines A. Ehrnstorfer; Cristina Manatschal; Fabian M. Arnold; Juerg Laederach; Raimund Dutzler

doi:10.1038/ncomms14033

Nature Communications (Jan 2017)

Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family

Ines A. Ehrnstorfer,
Cristina Manatschal,
Fabian M. Arnold,
Juerg Laederach,
Raimund Dutzler

Affiliations

Ines A. Ehrnstorfer: Department of Biochemistry, University of Zurich
Cristina Manatschal: Department of Biochemistry, University of Zurich
Fabian M. Arnold: Department of Biochemistry, University of Zurich
Juerg Laederach: Department of Biochemistry, University of Zurich
Raimund Dutzler: Department of Biochemistry, University of Zurich

DOI: https://doi.org/10.1038/ncomms14033
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Cellular uptake of transition metal ions is mediated by members of the SLC11/NRAMP family. Here the authors determine the structural and functional properties of EcoDMT, a bacterial SLC11 transporter, gathering molecular insight into its transport mechanism and proton coupling process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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