Mıcroınvasıve Breast Carcınoma: A Clınıcopathologıcal Evaluatıon Of Twenty-Seven Cases

Abstract

INTRODUCTION: The World Health Organisation defines microinvasive breast carcinoma (MIBC) as a lesion characterized by a single or multiple microscopic foci infiltrating the breast stroma, equal to 1 mm in size or smaller. The present study aims to investigate the impact of clinical and pathological parameters on the recurrence, metastasis, and prognosis in patients with the MIBC. METHODS: A group of patients diagnosed with breast cancer from January2006 to December2014 were examined retrospectively. Patients diagnosed with the MIBC were included in the study. A histopathological examination included the type of the invasive breast carcinoma, nuclear grade, number of microinvasive foci, presence of a lymph node metastasis, and hormone receptor status, diameter and grade and hormone receptor status of insitu component. In addition, local recurrence, distant metastasis, and survival characteristics and their relationship to the histopathological parameters were evaluated RESULTS: Twenty-seven patients with the MIBC were included in the study. All the patients were female. Median age was 56(25-78). Median follow-up duration was 51(15-130)months. Among 27cases of MIBC, clinical follow-up information was availiable in 25cases. There were only one invasive focus in 13 (48.1%) and multiple invasive focus in 14 (51.9%) patients. Five year disease free survival was 86.7% and 5year overall survival was91.4%. The number of microinvasive foci and ductal carcinoma in situ diamater and nuclear grade and hormone receptore expression were not related to recurrence and survival. DISCUSSION AND CONCLUSION: The number of microinvasive foci and ductal carcinoma in situ diamater and nuclear grade and hormone receptore expression were not related to recurrence and survival.

Keywords

• breast cancer
• microinvasive
• prognosis