Clinical Features and Prognosis of 74 Cases of Lymphoblastic Lymphoma

Abstract

Objective To analyze clinical features of lymphoblastic lymphoma(LBL), compare clinical and prognostic characteristics of B lymphoblasts lymphoma (B-LBL) and T lymphoblasts lymphoma (T-LBL), and the prognosis of various chemotherapy regimens on LBL. Methods Total 74 patients with LBL were collected from 2007 to 2014 at Tianjin Medical University Cancer Institute and Hospital. Descriptive analysis was used to analyze the disease spectrum characteristics of LBL. Results The median age of 74 LBL patients was 19.5 years, among which 45 cases were male, 60 cases were late onset (Ann-Arbor stage Ⅲ-Ⅳ), 42 patients had B symptoms, 32 cases had bone marrow involvement. The overall response rate (ORR) of the whole group was 70.2%, the complete response rate was 48.6%, and the 3-and 5-year overall survival rates were 38.0% and 26.6%, respectively. The 3-and 5-year progression-free survival rates were 34.8% and 23.2%, respectively. Seventeen patients were B-LBL and 57 cases were T-LBL. Compared with T-LBL, B-LBL was more likely to occur in children and associated with the onset of anemia. There was no significant difference in the survival between B-LBL and T-LBL patients. Univariate analysis showed that whether age < 18 years old, whether with anemia, the level of β2-MG, induction therapy regimens, the short-term efficacy were the related factors for prognosis. Conclusion Lymphoblastic lymphoma is a highly aggressive malignant non-Hodgkin' s lymphoma, with short lifetime, easy to occur in young people, usually late in the onset of the disease prone to bone marrow metastasis. Patients with ALL chemotherapy regimens may have better prognosis than those with CHOP-like regimens.

Keywords

• lymphoblastic lymphoma
• b cells
• t cells
• clinical characteristics
• prognosis