For better or worse: crosstalk of parvovirus and host DNA damage response

Songbiao Chen; Songbiao Chen; Songbiao Chen; Songbiao Chen; Feifei Liu; Feifei Liu; Feifei Liu; Aofei Yang; Aofei Yang; Aofei Yang; Ke Shang; Ke Shang; Ke Shang

doi:10.3389/fimmu.2024.1324531

Frontiers in Immunology (Feb 2024)

For better or worse: crosstalk of parvovirus and host DNA damage response

Songbiao Chen,
Songbiao Chen,
Songbiao Chen,
Songbiao Chen,
Feifei Liu,
Feifei Liu,
Feifei Liu,
Aofei Yang,
Aofei Yang,
Aofei Yang,
Ke Shang,
Ke Shang,
Ke Shang

Affiliations

Songbiao Chen: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Songbiao Chen: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, China
Songbiao Chen: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Songbiao Chen: Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China
Feifei Liu: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Feifei Liu: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, China
Feifei Liu: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Aofei Yang: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Aofei Yang: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, China
Aofei Yang: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Ke Shang: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Ke Shang: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, China
Ke Shang: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China

DOI: https://doi.org/10.3389/fimmu.2024.1324531
Journal volume & issue: Vol. 15

Abstract

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Parvoviruses are a group of non-enveloped DNA viruses that have a broad spectrum of natural infections, making them important in public health. NS1 is the largest and most complex non-structural protein in the parvovirus genome, which is indispensable in the life cycle of parvovirus and is closely related to viral replication, induction of host cell apoptosis, cycle arrest, DNA damage response (DDR), and other processes. Parvovirus activates and utilizes the DDR pathway to promote viral replication through NS1, thereby increasing pathogenicity to the host cells. Here, we review the latest progress of parvovirus in regulating host cell DDR during the parvovirus lifecycle and discuss the potential of cellular consequences of regulating the DDR pathway, targeting to provide the theoretical basis for further elucidation of the pathogenesis of parvovirus and development of new antiviral drugs.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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