Nature Communications (Oct 2020)

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

  • Hyunji Moon,
  • Chanhyuk Min,
  • Gayoung Kim,
  • Deokhwan Kim,
  • Kwanhyeong Kim,
  • Sang-Ah Lee,
  • Byeongjin Moon,
  • Susumin Yang,
  • Juyeon Lee,
  • Seung-Joo Yang,
  • Steve K. Cho,
  • Gwangrog Lee,
  • Chang Sup Lee,
  • Chul-Seung Park,
  • Daeho Park

DOI
https://doi.org/10.1038/s41467-020-19272-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.