Genetic mapping and evolutionary analysis of human-expanded cognitive networks

Yongbin Wei; Siemon C. de Lange; Lianne H. Scholtens; Kyoko Watanabe; Dirk Jan Ardesch; Philip R. Jansen; Jeanne E. Savage; Longchuan Li; Todd M. Preuss; James K. Rilling; Danielle Posthuma; Martijn P. van den Heuvel

doi:10.1038/s41467-019-12764-8

Nature Communications (Oct 2019)

Genetic mapping and evolutionary analysis of human-expanded cognitive networks

Yongbin Wei,
Siemon C. de Lange,
Lianne H. Scholtens,
Kyoko Watanabe,
Dirk Jan Ardesch,
Philip R. Jansen,
Jeanne E. Savage,
Longchuan Li,
Todd M. Preuss,
James K. Rilling,
Danielle Posthuma,
Martijn P. van den Heuvel

Affiliations

Yongbin Wei: Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Siemon C. de Lange: Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Lianne H. Scholtens: Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Kyoko Watanabe: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Dirk Jan Ardesch: Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Philip R. Jansen: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Jeanne E. Savage: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Longchuan Li: Marcus Autism Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Todd M. Preuss: Division of Neuropharmacology and Neurologic Diseases, Emory University
James K. Rilling: Center for Translational Social Neuroscience, Emory University
Danielle Posthuma: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Martijn P. van den Heuvel: Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam

DOI: https://doi.org/10.1038/s41467-019-12764-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Several cortical association areas have rapidly expanded in size during human evolution, including elements of the central cognitive default mode network (DMN). Here, the authors show that genes highly divergent between humans and other primates (HAR genes) are particularly expressed in these brain regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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