Anticancer properties of sulforaphane: current insights at the molecular level

Muhammad Asif Ali; Noohela Khan; Nabeeha Kaleem; Waqas Ahmad; Salem Hussain Alharethi; Bandar Alharbi; Hassan H. Alhassan; Maher M. Al-Enazi; Ahmad Faizal Abdull Razis; Ahmad Faizal Abdull Razis; Babagana Modu; Babagana Modu; Daniela Calina; Javad Sharifi-Rad

doi:10.3389/fonc.2023.1168321

Frontiers in Oncology (Jun 2023)

Anticancer properties of sulforaphane: current insights at the molecular level

Muhammad Asif Ali,
Noohela Khan,
Nabeeha Kaleem,
Waqas Ahmad,
Salem Hussain Alharethi,
Bandar Alharbi,
Hassan H. Alhassan,
Maher M. Al-Enazi,
Ahmad Faizal Abdull Razis,
Ahmad Faizal Abdull Razis,
Babagana Modu,
Babagana Modu,
Daniela Calina,
Javad Sharifi-Rad

Affiliations

Muhammad Asif Ali: Department of Food Science and Human Nutrition, University of Veterinary & Animal Sciences, Lahore, Pakistan
Noohela Khan: Department of Nutrition Sciences, Rashid Latif Medical College, Lahore, Pakistan
Nabeeha Kaleem: Department of Food Science and Human Nutrition, University of Veterinary & Animal Sciences, Lahore, Pakistan
Waqas Ahmad: Department of Food Science and Human Nutrition, University of Veterinary & Animal Sciences, Lahore, Pakistan
Salem Hussain Alharethi: Department of Biological Science, College of Arts and Science, Najran University, Najran, Saudi Arabia
Bandar Alharbi: Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha’il, Hail, Saudi Arabia
Hassan H. Alhassan: Department of Clinical Laboratory Science, College of Applied medical Sciences, Jouf University, Sakaka, Saudi Arabia
Maher M. Al-Enazi: Department of Medical Laboratory Sciences, College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
Ahmad Faizal Abdull Razis: Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Ahmad Faizal Abdull Razis: Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Babagana Modu: Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Babagana Modu: Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Borno, Nigeria
Daniela Calina: 0Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Javad Sharifi-Rad: 1Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador

DOI: https://doi.org/10.3389/fonc.2023.1168321
Journal volume & issue: Vol. 13

Abstract

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Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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