PLoS ONE (Jan 2015)

PSCA rs2294008 Polymorphism with Increased Risk of Cancer.

  • Peiliang Geng,
  • Jianjun Li,
  • Ning Wang,
  • Juanjuan Ou,
  • Ganfeng Xie,
  • Chen Liu,
  • Xiaoxin Zhao,
  • Lisha Xiang,
  • Yunmei Liao,
  • Houjie Liang

DOI
https://doi.org/10.1371/journal.pone.0136269
Journal volume & issue
Vol. 10, no. 8
p. e0136269

Abstract

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Published data on the association between PSCA rs2294008 polymorphism and cancer risk have implicated inconclusive results. To determine the relationship and to precisely assess the effect size estimate of the association, we performed a meta-analysis.We searched published literature in Embase and PubMed databases using the search terms "PSCA", "prostate stem cell antigen", "variants", "polymorphism", "polymorphisms", and "cancer". A total of 21 eligible articles were retrieved, with 27, 197 cancer cases and 48, 237 controls.On the whole, we found the association between PSCA rs2294008 polymorphism and cancer risk was statistically significant: TT vs CC: OR = 1.18, 95% CI, 1.10 to 1.27; TT + CT vs CC: OR = 1.08, 95% CI, 1.05 to 1.10; TT vs CT + CC: OR = 1.14, 95% CI, 1.07 to 1.21; T vs C: OR = 1.10, 95% CI, 1.06 to 1.14; CT vs CC: OR = 1.10, 95% CI, 1.06 to 1.13. Stratified analyses in cancer type and ethnicity showed similar results.Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.