Nature Communications (Mar 2023)

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

  • Matteo Maria Naldini,
  • Gabriele Casirati,
  • Matteo Barcella,
  • Paola Maria Vittoria Rancoita,
  • Andrea Cosentino,
  • Carolina Caserta,
  • Francesca Pavesi,
  • Erika Zonari,
  • Giacomo Desantis,
  • Diego Gilioli,
  • Matteo Giovanni Carrabba,
  • Luca Vago,
  • Massimo Bernardi,
  • Raffaella Di Micco,
  • Clelia Di Serio,
  • Ivan Merelli,
  • Monica Volpin,
  • Eugenio Montini,
  • Fabio Ciceri,
  • Bernhard Gentner

DOI
https://doi.org/10.1038/s41467-023-36969-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 20

Abstract

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Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.