Prevalence and Associations of Co-occurrence of <i>NFE2L2</i> Mutations and Chromosome 3q26 Amplification in Lung Cancer

Abstract

Background NFE2L2 (nuclear factor erythroid-2-related factor-2) encodes a basic leucine zipper (bZIP) transcription factor and exhibits variations in various tumor types, including lung cancer. In this study, we comprehensively investigated the impact of simultaneous mutations on the survival of NFE2L2-mutant lung cancer patients within specific subgroups.

Keywords

• NFE2L2
• lung cancer
• 3q36 amplification
• co-occurrence mutations
• next-generation sequencing