JACC: Basic to Translational Science (Sep 2022)

Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

  • Ardiansah Bayu Nugroho, PhD,
  • Nicholas Stafford, PhD,
  • Min Zi, PhD,
  • Sukhpal Prehar, MSc,
  • Ryan Potter, MRes,
  • Dowan Kwon, MRes,
  • Yulia Suciati Kohar, PhD,
  • Efta Triastuti, PhD,
  • Thuy Anh Bui, PhD,
  • Elizabeth J. Cartwright, PhD,
  • Delvac Oceandy, PhD

Journal volume & issue
Vol. 7, no. 9
pp. 859 – 875

Abstract

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Summary: Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.

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