Nature Communications (May 2021)
Sulfide catabolism ameliorates hypoxic brain injury
- Eizo Marutani,
- Masanobu Morita,
- Shuichi Hirai,
- Shinichi Kai,
- Robert M. H. Grange,
- Yusuke Miyazaki,
- Fumiaki Nagashima,
- Lisa Traeger,
- Aurora Magliocca,
- Tomoaki Ida,
- Tetsuro Matsunaga,
- Daniel R. Flicker,
- Benjamin Corman,
- Naohiro Mori,
- Yumiko Yamazaki,
- Annabelle Batten,
- Rebecca Li,
- Tomohiro Tanaka,
- Takamitsu Ikeda,
- Akito Nakagawa,
- Dmitriy N. Atochin,
- Hideshi Ihara,
- Benjamin A. Olenchock,
- Xinggui Shen,
- Motohiro Nishida,
- Kenjiro Hanaoka,
- Christopher G. Kevil,
- Ming Xian,
- Donald B. Bloch,
- Takaaki Akaike,
- Allyson G. Hindle,
- Hozumi Motohashi,
- Fumito Ichinose
Affiliations
- Eizo Marutani
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Masanobu Morita
- Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Shuichi Hirai
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Shinichi Kai
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Robert M. H. Grange
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Yusuke Miyazaki
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Fumiaki Nagashima
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Lisa Traeger
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Aurora Magliocca
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Tomoaki Ida
- Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Tetsuro Matsunaga
- Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Daniel R. Flicker
- Department of Systems Biology, Harvard Medical School
- Benjamin Corman
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Naohiro Mori
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Yumiko Yamazaki
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Annabelle Batten
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Rebecca Li
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Tomohiro Tanaka
- Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences & Exploratory Research Center on Life and Living Systems & Center for Novel Science Initiatives, National Institutes of Natural Sciences
- Takamitsu Ikeda
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Akito Nakagawa
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Dmitriy N. Atochin
- Harvard Medical School
- Hideshi Ihara
- Department of Biological Science, Graduate School of Science, Osaka Prefecture University
- Benjamin A. Olenchock
- Harvard Medical School
- Xinggui Shen
- Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport
- Motohiro Nishida
- Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences & Exploratory Research Center on Life and Living Systems & Center for Novel Science Initiatives, National Institutes of Natural Sciences
- Kenjiro Hanaoka
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Christopher G. Kevil
- Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport
- Ming Xian
- Department of Chemistry, Brown University
- Donald B. Bloch
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Takaaki Akaike
- Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Allyson G. Hindle
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- Hozumi Motohashi
- Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University
- Fumito Ichinose
- Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s41467-021-23363-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.
