Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua

Abstract

The present research study was aimed to investigate the efficiency of selected medicinal plants against Plasmodium vivax. Crude methanolic extracts from the seeds of leaves of Datura stramonium, Parthenium hysterophorus, Calotropis procera, and Dodonaea viscosa were prepared. In addition, Atropine was also isolated from alkaloid components of Eucalyptus obliqua to evaluate their in vitro anti-plasmodial effects. It was observed that proguanil (positive control) and Atropine displayed strong anti-plasmodial activity (94.04 and 68.02%, respectively) against P. vivax at 0.1 mg/mL concentration while the leaf extracts of other medicinal plants did not exhibit any notable anti-plasmodial activity. It was concluded that alkaloids of E. obliqua plant’s extracts were rich in anti-plasmodial compound Atropine, which exhibit a remarkable anti-plasmodial activity against P. vivax. Anti-plasmodial action of medicinal plants are attributed to these phytochemicals. In vitro studies using medicinal plant’s extracts and standardized methods will help to make more powerful and cost-effective anti-plasmodial compounds.

Keywords

• medicinal plants
• methanolic extract
• anti-plasmodial activity
• atropine
• proguanil