Antioxidant, anticholinesterase and neurotrophic potentials of indigenous medicinal herbs of Bangladesh

Abstract

In Ayurvedic system of medicine, a variety of medicinal herbs are being prescribed for brain disorders, including mental dysfunction, indifference, and memory impairment. Neuropharmacological mechanisms of these herbs are poorly understood. A total of nineteen indigenous medicinal herbs of Bangladesh were investigated for their neuropharmacological potentials, including antioxidant, anticholinesterase, and neurotrophic activities. The antioxidant activity of plant ethanolic extracts was determined based on their DPPH free radical scavenging capacity. Acetylcholinesterase (AChE) inhibitory activity was determined by the colorimetric assay based on Ellman's method. The neurotrophic activity of plant extracts was measured based on their capacity to promote neurite outgrowth in a primary culture of hippocampal neurons. Of the herbs, Camellia sinensis, Terminalia chebula, Cinnamomum tamala, Terminalia bellirica, Phyllanthus emblica, and Curcuma longa exhibited remarkable antioxidant activity with IC50 values of [ J Adv Biotechnol Exp Ther 2022; 5(3.000): 702-711]

Keywords

• anticholinesterase activity; antioxidant; cinnamomum tamala; medicinal plants; neurotrophic effects