Zhongguo linchuang yanjiu (Jun 2023)
Effects of Buqi Wenyang Dingkuang Decoction on cognitive function and sleep quality in the treatment of upfloating of asthenia yang type mania
Abstract
Objective To investigate the efficacy and effects on cognitive function and sleep quality of Buqi Wenyang Dingkuang Decoction in treatment of mania patients with upfloating of asthenia yang type. Methods A total of 100 patients with mania who were hospitalized between January 2020 and January 2022 in the Affiliated Brain Hospital of Guangzhou Medical University were selected and divided into observation group and control group according to the random number table method (n=50, each) . Both group was given valproate sustained-release tablets and quetiapine tablets treatment, and the observation group was added with Buqi Wenyang Dingkuang Decoction. The treatment course of the 2 groups was 4 weeks. Treatment efficacy and incidence of adverse reactions were compared between two groups. The primary syndrome score, Clinical Global Impressions Scale (CGI) score, Pittsburgh Sleep Quality Index (PSQI) score and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score before and after treatment were compared between the two groups. Results The total effective rate was higher in the observation group than in the control group (90.00% vs 72.00%, χ2=5.263, P＜0.05) . The scores of mania, thirst not to drink, and limb cold at 4 weeks of treatment in the 2 groups were lower than those before treatment (P＜0.05) , and those of the observation group were lower than those of the control group (P＜0.01) . The BRMS scale score, CGI score, and PSQI scale score of the 2 groups at 4 weeks of treatment were lower than those before treatment (P＜0.01) , and the above-mentioned scores of the observation group were lower than those of the control group (P＜0.01) . The scores of immediate memory, spatial structure, attention, verbal function, and delayed memory in the 2 groups at 4 weeks of treatment were higher than those at pretreatment (P＜0.01) , and the scores in the observation group after treatment were higher than those in the control group (P＜0.05) . Fewer adverse reactions were observed in the observation group than those in the control group (8.00% vs 26.00%, P＜0.05) . Conclusion Buqi Wenyang Dingkuang Decoction has a certain effect on mania patients with upfloating of asthenia yang type, and can significantly improve their cognitive function and sleep quality.
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