Nature Communications (May 2020)
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
- Daehong Kim,
- Giljun Park,
- Jani Huuhtanen,
- Sofie Lundgren,
- Rajiv K. Khajuria,
- Ana M. Hurtado,
- Cecilia Muñoz-Calleja,
- Laura Cardeñoso,
- Valle Gómez-García de Soria,
- Tzu Hua Chen-Liang,
- Samuli Eldfors,
- Pekka Ellonen,
- Sari Hannula,
- Matti Kankainen,
- Oscar Bruck,
- Anna Kreutzman,
- Urpu Salmenniemi,
- Tapio Lönnberg,
- Andrés Jerez,
- Maija Itälä-Remes,
- Mikko Myllymäki,
- Mikko A. I. Keränen,
- Satu Mustjoki
Affiliations
- Daehong Kim
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Giljun Park
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Jani Huuhtanen
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Sofie Lundgren
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Rajiv K. Khajuria
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Ana M. Hurtado
- Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB
- Cecilia Muñoz-Calleja
- Department of Immunology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa
- Laura Cardeñoso
- Department of Microbiology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa
- Valle Gómez-García de Soria
- Department of Hematology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa
- Tzu Hua Chen-Liang
- Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB
- Samuli Eldfors
- Institute of Molecular Medicine Finland (FIMM), University of Helsinki
- Pekka Ellonen
- Institute of Molecular Medicine Finland (FIMM), University of Helsinki
- Sari Hannula
- Institute of Molecular Medicine Finland (FIMM), University of Helsinki
- Matti Kankainen
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Oscar Bruck
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Anna Kreutzman
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Urpu Salmenniemi
- Stem Cell transplantation unit, Turku University Hospital
- Tapio Lönnberg
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Andrés Jerez
- Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB
- Maija Itälä-Remes
- Stem Cell transplantation unit, Turku University Hospital
- Mikko Myllymäki
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Mikko A. I. Keränen
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- Satu Mustjoki
- Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-16115-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Chronic graft versus host disease (cGvHD) is a major cause of morbidity and mortality in allogeneic bone marrow transplantation. Here the authors identify a recurrent activating mTOR mutation in expanded donor T-cell clones of 3 cGvHD patients, which suggests somatic mutations may contribute to GvHD pathogenesis and opens avenues to targeted therapies.
