The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS

Tian-Chen Xiong; Ming-Cong Wei; Fang-Xu Li; Miao Shi; Hu Gan; Zhen Tang; Hong-Peng Dong; Tianzi Liuyu; Pu Gao; Bo Zhong; Zhi-Dong Zhang; Dandan Lin

doi:10.1038/s41467-022-33671-5

Nature Communications (Oct 2022)

The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS

Tian-Chen Xiong,
Ming-Cong Wei,
Fang-Xu Li,
Miao Shi,
Hu Gan,
Zhen Tang,
Hong-Peng Dong,
Tianzi Liuyu,
Pu Gao,
Bo Zhong,
Zhi-Dong Zhang,
Dandan Lin

Affiliations

Tian-Chen Xiong: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Ming-Cong Wei: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Fang-Xu Li: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Miao Shi: CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Hu Gan: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Zhen Tang: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Hong-Peng Dong: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Tianzi Liuyu: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Pu Gao: CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Bo Zhong: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Zhi-Dong Zhang: Department of Gastrointestinal Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University
Dandan Lin: Cancer Center, Renmin Hospital of Wuhan University

DOI: https://doi.org/10.1038/s41467-022-33671-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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The activity and stability of the cytosolic DNA sensor cGAS, a key mediator of innate antiviral immunity and autoimmunity, is fine-tuned by post-translational modifications. Here, the authors demonstrate that the ubiquitin E3 ligase ARIH1 catalyzes the mono-ISGylation of cGAS and promotes its oligomerization in response to viral and self DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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