Frontiers in Microbiology (Dec 2021)
Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity
- Sijing Long,
- Sijing Long,
- Sijing Long,
- Sijing Long,
- Li Yang,
- Li Yang,
- Li Yang,
- Li Yang,
- Wei Dang,
- Wei Dang,
- Wei Dang,
- Wei Dang,
- Shuyu Xin,
- Shuyu Xin,
- Shuyu Xin,
- Shuyu Xin,
- Mingjuan Jiang,
- Mingjuan Jiang,
- Mingjuan Jiang,
- Mingjuan Jiang,
- Wentao Zhang,
- Wentao Zhang,
- Wentao Zhang,
- Wentao Zhang,
- Jing Li,
- Jing Li,
- Jing Li,
- Jing Li,
- Yiwei Wang,
- Yiwei Wang,
- Yiwei Wang,
- Yiwei Wang,
- Senmiao Zhang,
- Senmiao Zhang,
- Senmiao Zhang,
- Senmiao Zhang,
- Jianhong Lu,
- Jianhong Lu,
- Jianhong Lu,
- Jianhong Lu
Affiliations
- Sijing Long
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Sijing Long
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Sijing Long
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Sijing Long
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Li Yang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Li Yang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Li Yang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Li Yang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Wei Dang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Wei Dang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Wei Dang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Wei Dang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Shuyu Xin
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Shuyu Xin
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Shuyu Xin
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Shuyu Xin
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Mingjuan Jiang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Mingjuan Jiang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Mingjuan Jiang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Mingjuan Jiang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Wentao Zhang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Wentao Zhang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Wentao Zhang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Wentao Zhang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Jing Li
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jing Li
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Jing Li
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Jing Li
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Yiwei Wang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yiwei Wang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Yiwei Wang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Yiwei Wang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Senmiao Zhang
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Senmiao Zhang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Senmiao Zhang
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Senmiao Zhang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Jianhong Lu
- Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jianhong Lu
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Jianhong Lu
- NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Jianhong Lu
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fmicb.2021.805223
- Journal volume & issue
-
Vol. 12
Abstract
Deubiquitylating enzymes (DUBs) are proteases that crack the ubiquitin code from ubiquitylated substrates to reverse the fate of substrate proteins. Recently, DUBs have been found to mediate various cellular biological functions, including antiviral innate immune response mediated by pattern-recognition receptors (PRRs) and NLR Family pyrin domain containing 3 (NLRP3) inflammasomes. So far, many DUBs have been identified to exert a distinct function in fine-tuning antiviral innate immunity and are utilized by viruses for immune evasion. Here, the recent advances in the regulation of antiviral responses by DUBs are reviewed. We also discussed the DUBs-mediated interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antiviral innate immunity. The understanding of the mechanisms on antiviral innate immunity regulated by DUBs may provide therapeutic opportunities for viral infection.
Keywords
- deubiquitylating enzymes
- virus
- innate immunity
- pattern-recognition receptors
- immune evasion
- inflammasome
