SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

David Walter; Saskia Hoffmann; Eirini-Stavroula Komseli; Juri Rappsilber; Vassilis Gorgoulis; Claus Storgaard Sørensen

doi:10.1038/ncomms10530

Nature Communications (Jan 2016)

SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

David Walter,
Saskia Hoffmann,
Eirini-Stavroula Komseli,
Juri Rappsilber,
Vassilis Gorgoulis,
Claus Storgaard Sørensen

Affiliations

David Walter: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Saskia Hoffmann: Biotech Research and Innovation Centre (BRIC), University of Copenhagen
Eirini-Stavroula Komseli: Department of Histology and Embryology, School of Medicine, University of Athens
Juri Rappsilber: Wellcome Trust Centre for Cell Biology, University of Edinburgh
Vassilis Gorgoulis: Department of Histology and Embryology, School of Medicine, University of Athens
Claus Storgaard Sørensen: Biotech Research and Innovation Centre (BRIC), University of Copenhagen

DOI: https://doi.org/10.1038/ncomms10530
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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