Revista da Sociedade Brasileira de Medicina Tropical (Dec 2019)

Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

  • Milena Polotto,
  • Tiago Casella,
  • Fernanda Modesto Tolentino,
  • Mayra Mioto Mataruco,
  • Naiady Konno Madela Porto,
  • Mirella Fontana Batista Binhardi,
  • Mara Corrêa Lelles Nogueira

DOI
https://doi.org/10.1590/0037-8682-0094-2019
Journal volume & issue
Vol. 53

Abstract

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Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

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