The Carbapenemase BKC-1 from Klebsiella pneumoniae Is Adapted for Translocation by Both the Tat and Sec Translocons

Manasa Bharathwaj; Chaille T. Webb; Grishma Vadlamani; Christopher J. Stubenrauch; Tracy Palmer; Trevor Lithgow

doi:10.1128/mBio.01302-21

mBio (Jun 2021)

The Carbapenemase BKC-1 from Klebsiella pneumoniae Is Adapted for Translocation by Both the Tat and Sec Translocons

Manasa Bharathwaj,
Chaille T. Webb,
Grishma Vadlamani,
Christopher J. Stubenrauch,
Tracy Palmer,
Trevor Lithgow

Affiliations

Manasa Bharathwaj: Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia
Chaille T. Webb: Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia
Grishma Vadlamani: Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia
Christopher J. Stubenrauch: ORCiD; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia
Tracy Palmer: Microbes in Health and Disease, Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
Trevor Lithgow: ORCiD; Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria, Australia

DOI: https://doi.org/10.1128/mBio.01302-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Bacteria can readily acquire plasmids via lateral gene transfer (LGT). These plasmids can carry genes for virulence and antimicrobial resistance (AMR).

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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