Persistent telomere cohesion protects aged cells from premature senescence

Kameron Azarm; Amit Bhardwaj; Eugenie Kim; Susan Smith

doi:10.1038/s41467-020-17133-4

Nature Communications (Jul 2020)

Persistent telomere cohesion protects aged cells from premature senescence

Kameron Azarm,
Amit Bhardwaj,
Eugenie Kim,
Susan Smith

Affiliations

Kameron Azarm: Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine
Amit Bhardwaj: Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine
Eugenie Kim: Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine
Susan Smith: Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-17133-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Telomere function is regulated by the telomere repeat binding proteins TRF1 and TRF2. Here the authors show that decreased levels of TRF1 proteins at shortened telomeres in aged human cells results in persistent telomere cohesion, protecting from premature senescence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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