BMJ Open (Sep 2022)

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

  • ,
  • Oliver Burton,
  • Julie Woodfield,
  • Daniel Richardson,
  • Giles Critchley,
  • Angelos Kolias,
  • Thomas Santarius,
  • Lewis Thorne,
  • Peter Whitfield,
  • Ola Rominiyi,
  • Bharti Kewlani,
  • Harsh Bhatt,
  • Ahmed Ahmed,
  • Michael O’Sullivan,
  • Rasheed Zakaria,
  • Michael D Jenkinson,
  • Gerard Thompson,
  • Paul M Brennan,
  • Rory Piper,
  • Seong Hoon Lee,
  • Neil Barua,
  • Engelbert Mthunzi,
  • Sara Venturini,
  • Daniel M Fountain,
  • Najma Ahmed,
  • Stephen J Price,
  • Colin Watts,
  • Michael T C Poon,
  • Stuart Smith,
  • Anand Pandit,
  • Ryan K Mathew,
  • Soham Bandyopadhyay,
  • Rosa Sun,
  • Setthasorn Zhi Yang Ooi,
  • Victoria Wykes,
  • William Bolton,
  • Abdullah Egiz,
  • Samantha J Mills,
  • Babar Vaqas,
  • Natalie Simon,
  • Puneet Plaha,
  • Georgios Solomou,
  • Aswin Chari,
  • Grainne McKenna,
  • Melissa Gough,
  • Simon Lammy,
  • Sophie T Williams,
  • Isabelle Williams,
  • Andrew J Martin,
  • Sam Hodgson,
  • Robert Spencer,
  • Adam Waldman,
  • Armin Nazari,
  • Joshua Erhabor,
  • Omar Salim,
  • Saad Moughal,
  • Chinedu Brian Egu,
  • Abdurrahman I Islim,
  • Christopher P Millward,
  • Suhaib Abualsaud,
  • Michael Amoo,
  • Neeraj Kalra,
  • Agbolahan Sofela,
  • Thomas C Booth,
  • George E Richardson,
  • Conor S Gillespie,
  • Orla Mantle,
  • Abigail Clynch,
  • Jay J Park,
  • Emily R Bligh,
  • Avani Shanbhag,
  • Moritz Steinruecke,
  • Alvaro Yanez Touzet,
  • Hannah Redpath,
  • Gideon Adegboyega,
  • Prithvi Bahu,
  • Rosaline de Koning,
  • Tomas Ferreira,
  • Dana Hutton,
  • Jashan Selvakumar,
  • Tiffany TS Ye,
  • Ashvin Kuri,
  • Robin Borchert,
  • Bea Duric,
  • Elena Roman,
  • Kristy Kehoe,
  • Jeremy Cheong,
  • Lauren Harris,
  • Mohammad A Mustafa,
  • Hidayatul Abdullmalek,
  • Chinelo Afulukwe,
  • Abdelsalam Nedal Al-Sousi,
  • Yahia Al-Tamimi,
  • Ajitesh Anand,
  • Peter Bodkin,
  • Ion Boiangiu,
  • Abbey Boyle,
  • Christiaan Bredell,
  • Talhah Chaudri,
  • Ana Cios,
  • Iona Cleer,
  • David Coope,
  • Ian Coulter,
  • Harriet Davis,
  • Paolo Jose De Luna,
  • Nayan Dey,
  • Justyna O Ekert,
  • Jinendra Ekanayake,
  • Anna Elso,
  • Tom Flannery,
  • Kwan Wai Fung,
  • Rahul Ganguly,
  • Sanay Goyal,
  • Emily Hardman,
  • Theodore Hirst,
  • Kelvin Sunn Hoah,
  • Kismet Hossain-Ibrahim,
  • Lena Mary Houlihan,
  • Sami Squali Houssaini,
  • Sadid Hoque,
  • Mahnoor Javed,
  • Siddarth Kannan,
  • Efthymia Maria Kapasouri,
  • Andrew Keenlyside,
  • Prerna Khanna,
  • Kunalika Sathish Kumar,
  • Eunkyung Lee,
  • Robert Magouirk,
  • Riccardo Masina,
  • Adele Mazzoleni,
  • Patrick McAleavey,
  • Daniel McSweeney,
  • Trinh Ton Nu Ngoc,
  • Shiva A Nischal,
  • Jonathan Pesic-Smith,
  • Peter Peterson,
  • Isaac Phang,
  • Shyam Pujara,
  • Marwa Mohammed Elrasheed Saad,
  • Shinjan Sangal,
  • Veekshith Shetty,
  • Irtiza Syed,
  • Jesvin Tom Sunny,
  • Anca-Mihaela Vasilica,
  • Daniel O’Flaherty,
  • Arslan Khaliq Raja,
  • Daniele Ramsay,
  • Renitha Reddi,
  • Dorina Roy,
  • Jeremiah Samkutty,
  • Edward Jerome St George,
  • Preethi Subramanian,
  • Vaibhav Sundaresan,
  • Kieron Sweeney,
  • Boon Hoe Tan,
  • Nicole Turnbull,
  • Yuewei Tao,
  • Rebecca Tweedie,
  • Anastasia Tzatzidou,
  • Kathrin Whitehouse,
  • Jack Wildman,
  • Karl Williams,
  • Kelvin Sunn Yap,
  • Mahir Yousuff,
  • Asaad Zulfiqar,
  • Sophie Camp,
  • Setthasorn ZY Ooi

DOI
https://doi.org/10.1136/bmjopen-2022-063043
Journal volume & issue
Vol. 12, no. 9

Abstract

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Introduction Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12–15 months (range 6–17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use of postoperative imaging to detect progression is of high importance to clinicians and patients, but currently, the optimal follow-up schedule is yet to be defined. It is also unclear how adhering to National Institute for Health and Care Excellence (NICE) guidelines—which are based on general consensus rather than evidence—affects patient outcomes such as progression-free and overall survival. The primary aim of this study is to assess MRI monitoring practice after surgery for glioblastoma, and to evaluate its association with patient outcomes.Methods and analysis ImagiNg Timing aftER surgery for glioblastoma: an eVALuation of practice in Great Britain and Ireland is a retrospective multicentre study that will include 450 patients with an operated glioblastoma, treated with any adjuvant therapy regimen in the UK and Ireland. Adult patients ≥18 years diagnosed with glioblastoma and undergoing surgery between 1 August 2018 and 1 February 2019 will be included. Clinical and radiological scanning data will be collected until the date of death or date of last known follow-up. Anonymised data will be uploaded to an online Castor database. Adherence to NICE guidelines and the effect of being concordant with NICE guidelines will be identified using descriptive statistics and Kaplan-Meier survival analysis.Ethics and dissemination Each participating centre is required to gain local institutional approval for data collection and sharing. Formal ethical approval is not required since this is a service evaluation. Results of the study will be reported through peer-reviewed presentations and articles, and will be disseminated to participating centres, patients and the public.