Nature Communications (Feb 2019)

Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes

  • Vijayalakshmi V. Subramanian,
  • Xuan Zhu,
  • Tovah E. Markowitz,
  • Luis A. Vale-Silva,
  • Pedro A. San-Segundo,
  • Nancy M. Hollingsworth,
  • Scott Keeney,
  • Andreas Hochwagen

DOI
https://doi.org/10.1038/s41467-019-08875-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Meiotic recombination density is increased on shorter chromosomes. Here the authors show that recombination initiation continues near all chromosome ends long after interstitial regions become quiescent in a process that proportionally benefits short chromosomes.