Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

Hongming Miao; Juanjuan Ou; Yuan Peng; Xuan Zhang; Yujuan Chen; Lijun Hao; Ganfeng Xie; Zhe Wang; Xueli Pang; Zhihua Ruan; Jianjun Li; Liqing Yu; Bingzhong Xue; Hang Shi; Chunmeng Shi; Houjie Liang

doi:10.1038/ncomms11716

Nature Communications (May 2016)

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

Hongming Miao,
Juanjuan Ou,
Yuan Peng,
Xuan Zhang,
Yujuan Chen,
Lijun Hao,
Ganfeng Xie,
Zhe Wang,
Xueli Pang,
Zhihua Ruan,
Jianjun Li,
Liqing Yu,
Bingzhong Xue,
Hang Shi,
Chunmeng Shi,
Houjie Liang

Affiliations

Hongming Miao: Department of Oncology, Southwest Hospital, The Third Military Medical University
Juanjuan Ou: Department of Oncology, Southwest Hospital, The Third Military Medical University
Yuan Peng: Department of Oncology, Southwest Hospital, The Third Military Medical University
Xuan Zhang: Department of Oncology, Southwest Hospital, The Third Military Medical University
Yujuan Chen: Department of Oncology, Southwest Hospital, The Third Military Medical University
Lijun Hao: Department of Oncology, Southwest Hospital, The Third Military Medical University
Ganfeng Xie: Department of Oncology, Southwest Hospital, The Third Military Medical University
Zhe Wang: Department of Oncology, Southwest Hospital, The Third Military Medical University
Xueli Pang: Department of Oncology, Southwest Hospital, The Third Military Medical University
Zhihua Ruan: Department of Oncology, Southwest Hospital, The Third Military Medical University
Jianjun Li: Department of Oncology, Southwest Hospital, The Third Military Medical University
Liqing Yu: Department of Animal and Avian Sciences, University of Maryland
Bingzhong Xue: Department of Biology, Georgia State University
Hang Shi: Department of Biology, Georgia State University
Chunmeng Shi: Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University
Houjie Liang: Department of Oncology, Southwest Hospital, The Third Military Medical University

DOI: https://doi.org/10.1038/ncomms11716
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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