Clinical and Experimental Ocular Trauma and Infection (Jan 2024)
Does Epiphora Cause Meibomian Gland Loss and Dry Eye?
Abstract
Purpose To investigate the effects of epiphora due to primary acquired nasolacrimal duct obstruction (PANDO) and external dacryocystorhinostomy (DCR) for its treatment on meibomian glands and tear film parameters. Methods External DCR for unilateral PANDO in the Department of Ophthalmology, Faculty of Medicine, Bursa Uludag University between January 2018-June 2019 were reviewed. The tear film parameters and meibography measurement recorded at the preoperative and follow-up examinations were examined on both the obstructed side and the patent side. SPSS 23 was used for statistical analyzed. Results There was a significant difference between Schirmer-1 score before external DCR (13,1±5,0; 6,3±5,0; p=0,01) and this difference disappeared after surgery (12,0±7,3; 7,7±5,0; p=0,06). Postoperative increase in non-invasive average break-up time (niAVG-BUT) on operated side was statistically significant (10,5±4,6; 12,0±5,3; p=0,033). When the healthy and operated sides were compared with each other, no significant difference was observed in niAVG-BUT before and after surgery (p=0,907, p=0,614). Mean meibomian gland losses were decreased in both operated and patent sides postoperatively and these values were statistically significant (33,0±8,2; 27,1±6,8; p<0,001, 37,3±10,4; 31,4±9,6; p=0,01). Conclusion Patients with unilateral nasolacrimal duct obstruction (NLDO) had loss of meibomian gland in both NLDO side and patent side. This loss was found to be significantly reduced on both obstructed and patent sides after successful surgical removal of the epiphora.
