Nature Communications (Feb 2018)

Localization of adaptive variants in human genomes using averaged one-dependence estimation

  • Lauren Alpert Sugden,
  • Elizabeth G. Atkinson,
  • Annie P. Fischer,
  • Stephen Rong,
  • Brenna M. Henn,
  • Sohini Ramachandran

DOI
https://doi.org/10.1038/s41467-018-03100-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Selective sweeps are events in which beneficial mutations spread rapidly through a population. Here, Sugden et al. develop SWIF(r), a probabilistic classification framework for detecting and localizing selective sweeps, and apply it to genomic data from the ‡Khomani San.