Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy

Yuqing Zhou; Qian Dong; Rong Zhang; Shunfeng Zhou; Linqiang Li; Keran Cheng; Rui Kong; Qiang Yu; Shizan Xu; Jingjing Li; Sainan Li; Jiao Feng; Liwei Wu; Tong Liu; Xiya Lu; Kan Chen; Yujing Xia; Jie Lu; Yingqun Zhou; Chuanyong Guo

doi:10.1155/2016/8485032

Gastroenterology Research and Practice (Jan 2016)

Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy

Yuqing Zhou,
Qian Dong,
Rong Zhang,
Shunfeng Zhou,
Linqiang Li,
Keran Cheng,
Rui Kong,
Qiang Yu,
Shizan Xu,
Jingjing Li,
Sainan Li,
Jiao Feng,
Liwei Wu,
Tong Liu,
Xiya Lu,
Kan Chen,
Yujing Xia,
Jie Lu,
Yingqun Zhou,
Chuanyong Guo

Affiliations

Yuqing Zhou: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Qian Dong: The Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China
Rong Zhang: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Shunfeng Zhou: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Linqiang Li: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Keran Cheng: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Rui Kong: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Qiang Yu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Shizan Xu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Jingjing Li: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Sainan Li: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Jiao Feng: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Liwei Wu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Tong Liu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Xiya Lu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Kan Chen: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Yujing Xia: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Jie Lu: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Yingqun Zhou: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China
Chuanyong Guo: Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China

DOI: https://doi.org/10.1155/2016/8485032
Journal volume & issue: Vol. 2016

Abstract

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Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4). Ammonia and cerebral hemodynamics (by TCD) were assessed. Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment. Results. Ammonia, Vm, Vd, PI, and RI were statistically different before treatment, and ammonia, PI, and RI levels paralleled the severity of HE (P0.05). Correlations were found between ammonia and Vd, PI, RI, NCT-A, and DST and also found between Vd, PI, RI, and NCT-A and DST (P<0.05). Conclusions. This study revealed that cerebral hemodynamics were related to the severity of HE and cerebral autoregulation was impaired. There were tight correlations among ammonia, cerebral hemodynamics, and cognitive function, and, following treatment, cerebral hemodynamics improved.

Published in Gastroenterology Research and Practice

ISSN: 1687-6121 (Print); 1687-630X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/6480

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