ANÁLISE DA REMODELAÇÃO CARDÍACA EM ANIMAIS COM INSUFICIÊNCIA CARDÍACA (IC) INDUZIDA PELA MONOCROTALINA SUBMETIDOS A TREINAMENTO FÍSICO PREVENTIVO

Abstract

The prevalence of Heart failure (HF) increases annually, being one of the reasons the raise of life expectancy. The Right Heart Failure (RHF) presents a big morbidity-mortality, being mainly related with Cor Pulmonale. There aren’t studies that evaluate repercussions of preventive physical training (RHF). The goal of this study was evaluation/impact of preventive physical training in rats with RHF inducted by monocrotaline. They used males Wistar rats, divided in 4 groups of 8 animals: control sedentary (C); control training (T); monocrotaline sedentary (M); monocrotaline training (TM). The protocol of training was realized in treadmill for 13 weeks, 5 fold/week (10 weeks of preventive training and 3 weeks after the monocrotaline shot). After this period the animals were killed and were analysed the anatomic parameters of heart, lung and liver. In conclusion the animals presented right ventricular dysfunction and the preventive training didn’t bring benefits in this cardiac parameter.

Keywords

• heart failure
• monocrotaline
• rats wistar
• physical conditioning animal
• isease prevention