Nature Communications (Sep 2017)
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
- Yidong Wang,
- Bingruo Wu,
- Pengfei Lu,
- Donghong Zhang,
- Brian Wu,
- Shweta Varshney,
- Gonzalo del Monte-Nieto,
- Zhenwu Zhuang,
- Rabab Charafeddine,
- Adam H. Kramer,
- Nicolas E. Sibinga,
- Nikolaos G. Frangogiannis,
- Richard N. Kitsis,
- Ralf H. Adams,
- Kari Alitalo,
- David J. Sharp,
- Richard P. Harvey,
- Pamela Stanley,
- Bin Zhou
Affiliations
- Yidong Wang
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Bingruo Wu
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Pengfei Lu
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Donghong Zhang
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Brian Wu
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Shweta Varshney
- Department of Cell Biology, Albert Einstein College of Medicine
- Gonzalo del Monte-Nieto
- Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute
- Zhenwu Zhuang
- Department of Medicine, Yale University
- Rabab Charafeddine
- Department of Physiology and Biophysics, Albert Einstein College of Medicine
- Adam H. Kramer
- Department of Physiology and Biophysics, Albert Einstein College of Medicine
- Nicolas E. Sibinga
- Departments of Medicine, Developmental and Molecular Biology, Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Nikolaos G. Frangogiannis
- Departments of Medicine, Microbiology and Immunology, Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Richard N. Kitsis
- Departments of Medicine and Cell Biology, Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- Ralf H. Adams
- Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine
- Kari Alitalo
- Wihuri Research Institute, Biomedicum Helsinki
- David J. Sharp
- Department of Physiology and Biophysics, Albert Einstein College of Medicine
- Richard P. Harvey
- Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute
- Pamela Stanley
- Department of Cell Biology, Albert Einstein College of Medicine
- Bin Zhou
- Departments of Genetics, Pediatrics, and Medicine (Cardiology), Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00654-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice and show that a DLL4/NOTCH1/VEGFA/VEGFR2 signaling axis is key for coronary artery development.
