CASPASE-3 and CASPASE-8 activity in right ventricular myocardial cells in experimental arterial hypertension

Abstract

Caspase-3 and caspase-8 activity in right ventricular myocardial cells of rabbits with experimental arterial hypertension (AH) was investigated. Caspase-3 activity significantly increased at 2 and 4 weeks after modeling of AH. Obtained data demonstrated increased apoptosis in right ventricular myocardial cells in experimental arterial hypertension. Absence of significant increasing of caspase-8 activity indicates the predominance of intrinsic apoptogenic signals.

Keywords

• апоптоз
• каспаза
• миокард
• артериальная гипертензия