Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka

Junpei Yamashita; Yuji Nishiike; Thomas Fleming; Daichi Kayo; Kataaki Okubo

doi:10.1038/s42003-021-02476-5

Communications Biology (Aug 2021)

Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka

Junpei Yamashita,
Yuji Nishiike,
Thomas Fleming,
Daichi Kayo,
Kataaki Okubo

Affiliations

Junpei Yamashita: Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yuji Nishiike: Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Thomas Fleming: Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Daichi Kayo: Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kataaki Okubo: Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s42003-021-02476-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Junpei Yamashita et al. use a medaka model to evaluate how neurons in the preoptic area that express the neuropeptides, PACAP and VIP, regulate pituitary hormones. Their results suggest that estrogen helps maintain sex-dependent activity of these neurons, leading to sexually dimorphic pituitary hormone production.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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