Aptamer-assisted tumor localization of bacteria for enhanced biotherapy

Zhongmin Geng; Zhenping Cao; Rui Liu; Ke Liu; Jinyao Liu; Weihong Tan

doi:10.1038/s41467-021-26956-8

Nature Communications (Nov 2021)

Aptamer-assisted tumor localization of bacteria for enhanced biotherapy

Zhongmin Geng,
Zhenping Cao,
Rui Liu,
Ke Liu,
Jinyao Liu,
Weihong Tan

Affiliations

Zhongmin Geng: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Zhenping Cao: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Rui Liu: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Ke Liu: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Jinyao Liu: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Weihong Tan: Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-021-26956-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Bacteria-based therapy has shown promise for cancer treatment. To enhance tumor accumulation, here the authors describe the design of tumor specific aptamer-conjugated bacteria, to improve intratumor localization and enhance therapeutic efficacy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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