Why not add some SPARKL to your life (and death)!?

Abstract

Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.

Keywords

• apoptosis
• cell death
• ferroptosis
• high-throughput
• kinetics
• live-cell imaging
• necroptosis
• proliferation
• real-time analysis
• sparkl