Apical Sparing Pattern of Longitudinal Strain and Positive Bone Scintigraphy in Metastatic Myocardial Calcification

Kathleen W. Zhang, MD; Justin S. Sadhu, MD, MPHS; Brent W. Miller, MD; Daniel C. Brennan, MD; Andrew J. Bierhals, MD, MPH; Jie-Fu Chen, MD; Chieh-Yu Lin, MD, PhD; Justin M. Vader, MD, MPHS

JACC: Case Reports (May 2020)

Apical Sparing Pattern of Longitudinal Strain and Positive Bone Scintigraphy in Metastatic Myocardial Calcification

Kathleen W. Zhang, MD,
Justin S. Sadhu, MD, MPHS,
Brent W. Miller, MD,
Daniel C. Brennan, MD,
Andrew J. Bierhals, MD, MPH,
Jie-Fu Chen, MD,
Chieh-Yu Lin, MD, PhD,
Justin M. Vader, MD, MPHS

Affiliations

Kathleen W. Zhang, MD: Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri; Address for correspondence: Dr. Kathleen W. Zhang, Cardiovascular Division, Washington University School of Medicine, Campus Box 8086, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093.
Justin S. Sadhu, MD, MPHS: Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
Brent W. Miller, MD: Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana
Daniel C. Brennan, MD: Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Andrew J. Bierhals, MD, MPH: Cardiothoracic Imaging Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
Jie-Fu Chen, MD: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri
Chieh-Yu Lin, MD, PhD: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri
Justin M. Vader, MD, MPHS: Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri

Journal volume & issue: Vol. 2, no. 5
pp. 809 – 813

Abstract

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An apical sparing pattern of longitudinal strain and positive radionuclide bone scintigraphy are believed to be specific for the diagnosis of transthyretin cardiac amyloidosis. We report on a young woman with apical sparing of longitudinal strain and positive bone scintigraphy who was found to have metastatic myocardial calcification at autopsy. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

About the journal

Abstract

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