Hemorrhagic stroke and COVID-19 infection: Coincidence or causality?

Pedro Fraiman; Mariana Freire; Manuel Moreira-Neto; Clecio Godeiro-Junior

eNeurologicalSci (Dec 2020)

Hemorrhagic stroke and COVID-19 infection: Coincidence or causality?

Pedro Fraiman,
Mariana Freire,
Manuel Moreira-Neto,
Clecio Godeiro-Junior

Affiliations

Pedro Fraiman: Division of Neurology, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil
Mariana Freire: Division of Radiology, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil
Manuel Moreira-Neto: Master's in Health Education (MPES), Graduate Program in Health Sciences (PPGCSa), Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil; Division of Radiology, Liga Norte Riograndense Contra o Câncer (LNRCC), Av. Miguel Castro, 1355, Dix-Sept Rosado, Natal, RN 59075-740, Brazil
Clecio Godeiro-Junior: Division of Neurology, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil; Master's in Health Education (MPES), Graduate Program in Health Sciences (PPGCSa), Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil; Corresponding author at: Division of Neurology, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil.

Journal volume & issue: Vol. 21
p. 100274

Abstract

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Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.

Published in eNeurologicalSci

ISSN: 2405-6502 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.journals.elsevier.com/eneurologicalsci/

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Abstract

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