DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Cristina Ribeiro-Silva; Özge Z. Aydin; Raquel Mesquita-Ribeiro; Jana Slyskova; Angela Helfricht; Jurgen A. Marteijn; Jan H. J. Hoeijmakers; Hannes Lans; Wim Vermeulen

doi:10.1038/s41467-018-06402-y

Nature Communications (Oct 2018)

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Cristina Ribeiro-Silva,
Özge Z. Aydin,
Raquel Mesquita-Ribeiro,
Jana Slyskova,
Angela Helfricht,
Jurgen A. Marteijn,
Jan H. J. Hoeijmakers,
Hannes Lans,
Wim Vermeulen

Affiliations

Cristina Ribeiro-Silva: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Özge Z. Aydin: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Raquel Mesquita-Ribeiro: School of Life Sciences, University of Nottingham
Jana Slyskova: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Angela Helfricht: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Jurgen A. Marteijn: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Jan H. J. Hoeijmakers: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Hannes Lans: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam
Wim Vermeulen: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam

DOI: https://doi.org/10.1038/s41467-018-06402-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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SWI/SNF genes are commonly found to be mutated in different cancers. Here the authors report that the remodelers BRM and BRG1 are necessary for efficient nucleotide excision repair by promoting the expression of TFIIH subunit GTF2H1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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