Meningococcal polyvaccine on the basis of cleared IgAI protease

Abstract

IgA1-protease allocated from the culture N. meningitidis serogroup A. As original materials were used three different intermediate products of vaccine production: cultural fluid, cetavlon supernatant and cetavlon precipitate. IgA1-protease was used to evaluate their protectivity and immunogenity. It was shown, that isolated IgA1 protease from the meningococcus serogroup A is able to protect mice, infected by meningococcus serogroup B.

Keywords

• IgA1 протеаза
• менингококк
• полисахарид
• поливалентная вакцина
• иммуногенность
• протективность