Nature Communications (Oct 2016)

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

  • Agatha A. van der Klaauw,
  • Julia M. Keogh,
  • Elana Henning,
  • Cheryl Stephenson,
  • Sarah Kelway,
  • Victoria M. Trowse,
  • Naresh Subramanian,
  • Stephen O’Rahilly,
  • Paul C. Fletcher,
  • I. Sadaf Farooqi

DOI
https://doi.org/10.1038/ncomms13055
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 5

Abstract

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Hypothalamic melanocortin-4-receptors (MC4R) regulate food preference in rodents, but their role in humans is unclear. Here, the authors perform food preference and liking tests in humans with MC4R mutations and find that they prefer fatty food more, but sweet food less, than people without MC4R mutations.